Pathogenic
by aberrant labs
You are a disease. Infect the human body as a lone pathogen in this cellular roguelike shooter. Collect organelles to evolve your parasite in a microscopic arms race against your host’s immune system. Conquer a beautiful, procedurally generated world of tiny proportions.
Simulation
Action
Psychedelic
Roguelike
Perma Death
Shooter
2D
Roguelite
Physics
Difficult
Singleplayer
Colorful
Top-Down Shooter
Twin Stick Shooter
Top-Down
Bullet Hell
Procedural Generation
God Game
Science
Nature
Action Roguelike
Looter Shooter
AVAILABLE ON PC
KEEP UP TO DATE ON SOCIALS
ABOUT THE GAME
CELLULAR COMBAT EVOLVED
In Pathogenic, you are the disease. Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and conquer your human host.
To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction. Create powerful, game-breaking builds and become the ultimate pathogen.
CREATE YOUR OWN PATHOGEN
Loot, graft, and assemble your parasite from dozens of unique organelles. Combine flagella for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Chain organelle effects and discover powerful synergies to build an unstoppable disease vector.
FIGHT THE IMMUNE SYSTEM
Battle a diverse roster of enemies, from basic immune cells like macrophages and T cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host’s organs.
METAPROGRESSION
Collect plasmid fragments to permanently upgrade your parasite’s plasmid tree between runs. Each parasite will have it’s own upgrade tree allowing for a range of builds to suit your preferred playstyle.
EXPLORE A MICROSCOPIC WORLD
Navigate the procedurally generated organic landscape of the human body. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.
FEEL THE ORGANIC ACTION
Our detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures endless variety – each run offers a fresh and challenging gameplay experience.












